JWH-081 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB₁ and CB₂ receptors.^[3] With a K_i of 1.2nM it is fairly selective for the CB₁ subtype, its affinity at this subtype is measured at approximately 10x the affinity at CB₂(12.4nM).^[4] It was discovered by and named after John W. Huffman.

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